専　門（臨床）

• 消化器内視鏡
• 炎症性腸疾患、胃炎（消化管における炎症性疾患）
• 血清ペプチド解析による大腸がん診断（基礎）

専　門（基礎）

• 大腸上皮細胞の増殖・分化・創傷治癒

所属学会

• 日本内科学会　総合内科専門医　指導医
• 日本消化器病学会　専門医　指導医　近畿支部評議員　学会評議員
• 日本消化器内視鏡学会　専門医　指導医　近畿支部評議員　学会評議員
• 日本消化管学会　胃腸専門医　指導医
• 日本潰瘍学会　評議員
• 日本酸化ストレス学会　評議員

業　績

1. Uchiyama K, Kobayashi Y, Tanaka R, Takahashi Y, Chikayama S, Ikeda M, Uoshima N, Kimura S, Tanaka K, Wada K, Ozawa M, Kondo M. Primary malignant lymphoma of the central nervous system presenting with ascites and pleural effusion. Haematologia. 30(2):143-8, 2000.
2. Uchiyama K, Yoshida N, Mizobuchi M, Higashihara H, Naito Y, Yoshikawa T. Mucosal IgA deposition in Henoch-Schonlein purpura (HSP) with duodenal ulcer. J Gastroenterol Hapatol 17: 728-729, 2002.
3. Uchiyama K, Naito Y, Hasegawa G, Nakamura N, Takahashi J, Yoshikawa T. Astaxanthin protects beta-cells against glucSeto Oxicity in diabetic db/db mice. Redox Rep 7: 290-3, 2002.
4. Uchiyama K, Ida K, Okuda J, Asai Y, Ohyama Y, Kuroda M, Matsumoto N, Takami T, Ogawa T, Takaori K. Correlations of Hemoglobin Index (IHb) of Gastric Mucosa with Helicobacter pylori (H pyroli) Infection and Inflammation of gastric mucosa. Scand J Gastroenteroli. 39(11):1054-60, 2004.
5. Uchiyama K, Takano H, Yanagisawa R, Inoue K, Naito Y, Yoshida N, Yoshino S, Murase H, Ichinose T, Yoshikawa T. A novel water-soluble vitamin E derivative prevents acute lung injury by bacterial endotoxin. Clin Exp Pharmacol Physiol 31: 226-30, 2004.
6. Musch MW, Arvans DL, Walsh-Reitz MM, Uchiyama K, Fukuda M, Chang EB: Synaptotagmin I binds intestinal epithelial NHE3 and mediates cyclic AMP- and Ca++-induced endocytosis by recruitment of AP2 and clathrin. Am J Physil Gastrointest Liver Physiol. Jun;292(6):G1549-58.Epub 2007.
7. Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Harusato A, Hirata I, Omatsu T, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T. Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts. Biochem Biophys Res Commun. 1;391(1):1122-6, 2010.
8. Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T. FGF19 protects colonic epithelial cells against hydrogen peroxide. Digestion. 83(3):180-3, 2011.
9. Uchiyama K, Naito Y, Takagi T, Mizushima K, Hirai Y, Hayashi N, Harusato A, Inoue K, Fukumoto K, Yamada S, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T. Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 15.
10. Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, Itoh Y. MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid. Cell Physiol Biochem. 2013;32(4):942-50.
11. Uchiyama K, Ishikawa T, Sakamoto N, Kajikawa H, Takagi T, Handa O, Tatsumi Y, Yagi N, Naito Y, Itoh Y, Takemura S. Analysis of cardiopulmonary stress during endoscopy: is unsedated transnasal esophagogastroduodenoscopy appropriate for elderly patients? Can J Gastroenterol Hepatol. 2014 Jan;28(1):31-4.
12. Uchiyama K, Takagi T, Iwamoto Y, Kondo N, Okayama T, Yoshida N, Kamada K, Katada K, Handa O, Ishikawa T, Yasuda H, Sakagami J, Konishi H, Yagi N, Naito Y, Itoh Y. New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid. PLoS One. 2014 Apr 24;9(4):e95080
13. Uchiyama K, Naito Y, Yagi N, Mizushima K, Higashimura Y, Hirai Y, Okayama T, Yoshida N, Katada K, Kamada K, Handa O, Ishikawa T, Takagi T, Konishi H, Nonaka D, Asada K, Lee Lyang-Ja, Tanaka K, Kuriu Y, Nakanishi M, Otsuji E, Itoh Y. Peptidomic Analysis via One-Step Direct Transfer Technology for Colorectal Cancer Biomarker Discovery. J Proteomics Bioinform. 2015 S5, http://dx.doi.org/10.4172/jpb.S5-005.
14. Horii Y, Uchiyama K, Toyokawa Y, Hotta Y, Tanaka M, Yasukawa Z, Tokunaga M, Okubo T, Mizushima K, Higashimura Y, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Handa O, Ishikawa T, Takagi T, Konishi H, Naito Y, Itoh Y. Partially hydrolyzed guar gum enhances colonic epithelial wound healing via activation of RhoA and ERK1/2. Food Funct. 2016 Jul 13;7(7):3176-83.
15. Uchiyama K, Sakiyama T, Hasebe T, Musch MW, Miyoshi H, Nakagawa Y, He TC, Lichtenstein L, Naito Y, Itoh Y, Yoshikawa T, Jabri B, Stappenbeck T, Chang EB. Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development. Sci Rep. 2016 Aug 26;6:32094.
16. Steiger C, Uchiyama K, Takagi T, Mizushima K, Higashimura Y, Gutmann M, Hermann C, Botov S, Schmalz HG, Naito Y, Meinel L. Prevention of colitis by controlled oral drug delivery of carbon monoxide. J Control Release. 2016 Aug 27. pii:S0168-3659(16)30598-3.
17. Uchiyama K, Yagi Y (equally contributed first author), Mizushima K, Higashimura Y, Hirai Y, Okayama T, Yoshida N, Katada K, Kamada K, Handa O, Ishikawa T, Takagi T, Konishi H, Kuriu Y, Nakanishi M, Otsuji E, Itoh Y, Naito Y. Serum metabolomics analysis for early detection of colorectal cancer. J Gastroenterol 2016 Sep 20.
18. Uchiyama K, Takagi T, Kashiwagi S, Toyokawa Y, Tanaka M, Hotta Y, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Ishikawa T, Handa O, Konishi H, Kishimoto M, Yagi N, Naito Y, Itoh Y. Assessment of endoscopic mucosal healing of ulcerative colitis using linked colour imaging, a novel endoscopic enhancement system. J Crohns Colitis. 2017 Aug 1;11(8):963-969.
19. Uchiyama K, Naito Y, Yagi N, Mizushima K, Higashimura Y, Hirai Y, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Handa O, Ishikawa T, Takagi T, Konishi H, Nonaka D, Asada K, Lyang-Ja Lee, Tanaka K, Kuriu Y, Nakanishi M, Otsuji E and Itoh Y. Selected reaction monitoring for colorectal cancer diagnosis using a set of five-serum peptides identified by BLOTCHIP®-MS analysis. J Gastronenterol 2018 Nov;53(11):1179-1185.
20. Uchiyama K, Naito Y, Takagi T. Intestinal microbiome as a novel therapeutic target for local and systemic inflammation. Pharmacol Ther 2019 Mar 12;S0163-7258(19)30045-2
21. Nakano T, Uchiyama K, Ushiroda C, Kashiwagi S, Toyokawa Y, Mizushima K, Inoue K, Dohi O, Okayama T, Yoshida N, Katada K, Handa O, Ishikawa T, Takagi T, Konishi H, Naito Y, Itoh Y. Promotion of wound healing by acetate in murine colonic epithelial cell via c-Jun N-terminal kinase activation. J Gastroenterol Hepatol. Jul;35(7):1171-1179, 2020
22. Uchiyama K, Takagi T, Mizushima K, Kajiwara-Kubota M, Kashiwagi S, Toyokawa Y, Tanaka M, Hotta Y, Kamada K, Ishikawa T, Konishi H, Kishimoto M, Naito Y, Itoh Y. Increased mucosal IL-12 expression is associates with relapse of ulcerative colitis. BMC Gastroenterol. Mar 17;21(1):122, 2021
23. Uchiyama K, Naito Y, Yagi N, Mizushima K, Higashimura Y, Hirai Y, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Ishikawa T, Takagi T, Konishi H, Kuriu Y, Nakanishi M, Otsuji E, Honda A, Itoh Y. Identification of colorectal neoplasia by using serum bile acid profile. Biomarkers. 2021 Jul;26(5):462-467.
24. Azuma Y, Uchiyama K, Sugaya T, Yasuda T, Hashimoto H, Kajiwara-Kubota M, Sugino S, Kitae H, Torii T, Mizushima K, Doi T, Inoue K, Dohi O, Yoshida N, Kamada K, Ishikawa T, Takagi T, Konishi H, Naito Y, Itoh Y. Deoxycholic acid delays the wound healing of colonic epithelial cells via transmembrane G-protein-coupled receptor 5. J Gastroenterol Hepatol. 2022 Jan;37(1):134-143.
25. Uchiyama K, Takagi T, Mizushima K, Asaeda K, Kajiwara M, Kashiwagi S, Toyokawa Y, Hotta Y, Tanaka M, Inoue K, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Ishikawa T, Yasuda H, Konishi H, Kishimoto M, Naito Y, Itoh Y. Mucosal interleukin-8 expression as a predictor of subsequent relapse in ulcerative colitis patients with Mayo endoscopic subscore. J Gastroenterol Hepatol. 2022 Mar 1 doi: 10.1111/jgh.15813. Online ahead of print.
26. Uchiyama K, Takagi T, Mizushima K, Asaeda K, Kajiwara M, Kashiwagi S, Toyokawa Y, Hotta Y, Tanaka M, Inoue K, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Ishikawa T, Yasuda H, Konishi H, Kishimoto M, Naito Y, Itoh Y. Investigation on the inhibitory effect of Wnt5a on colonic mucosal inflammation in patients with ulcerative colitis. 2022 Dig Dis Sci in press