専　門

• 消化器病学
• 消化器内視鏡学
• 消化管炎症学（炎症性腸疾患）

所属学会

• 日本内科学会（総合内科専門医・指導医）
• 日本消化器病学会　学会評議員（専門医・指導医）
  Clinical Journal of Gastroenterology編集委員　ICD-11検討委員会委員
• 日本消化器内視鏡学会　学会評議員（専門医・指導医）
• 日本消化管学会（胃腸科専門医・指導医）
• 日本酸化ストレス学会　代議員
  利益相反委員会委員　倫理委員会員会　選挙管理委員会委員
• 日本潰瘍学会　評議員
  利益相反・倫理委員会委員
• 日本炎症・再生学会　評議員
• 日本消化器免疫学会　評議員
  教育委員会委員
• 日本抗加齢医学会　評議員
• 日本微小循環学会　評議員
• 日本小腸学会　評議員
• 日本フードファクター学会 理事・評議員
• 日本がん治療認定医
• 日本医師会認定産業医
• 日本旅行学会認定医
• 日本炎症性腸疾患学会
  総務委員会委員

業　績

1. Takagi T, Homma T, Fujii J, Shirasawa N, Yoriki H, Hotta Y, Higashimura Y, Mizushima K, Hirai Y, Katada K, Uchiyama K, Naito Y, Itoh Y. Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice. Free Radic Biol Med. 2019 Apr;134:153-164.
2. Takagi T, Naito Y, Mizushima K, Hirai Y, Harusato A, Okayama T, Katada K, Kamada K, Uchiyama K, Handa O, Ishikawa T, Itoh Y. Heme oxygenase-1 prevents murine intestinal inflammation. J Clin Biochem Nutr. 2018 Nov;63(3):169-174.
3. Takagi T, Naito Y, Inoue R, Kashiwagi S, Uchiyama K, Mizushima K, Tsuchiya S, Dohi O, Yoshida N, Kamada K, Ishikawa T, Handa O, Konishi H, Okuda K, Tsujimoto Y, Ohnogi H, Itoh Y. Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects. J Gastroenterol. 2019 Jan;54(1):53-63. Erratum in: J Gastroenterol. 2018 Sep 6.
4. Takagi T, Naito Y, Tanaka M, Mizushima K, Ushiroda C, Toyokawa Y, Uchiyama K, Hamaguchi M, Handa O, Itoh Y. Carbon monoxide ameliorates murine T-cell-dependent colitis through the inhibition of Th17 differentiation. Free Radic Res. 2018 Dec;52(11-12):1328-1335.
5. Takagi T, Naito Y, Inoue R, Kashiwagi S, Uchiyama K, Mizushima K, Tsuchiya S, Okayama T, Dohi O, Yoshida N, Kamada K, Ishikawa T, Handa O, Konishi H, Okuda K, Tsujimoto Y, Ohnogi H, Itoh Y. The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study. J Clin Biochem Nutr. 2018 Jan;62(1):100-105.
6. Fuke N, Takagi T, Higashimura Y, Tsuji T, Umeda R, Mizushima K, Tanaka M, Suganuma H, Aizawa K, Yajima N, Naito Y. Lactobacillus brevis KB290 With Vitamin A Ameliorates Murine Intestinal Inflammation Associated With the Increase of CD11c+ Macrophage/CD103- Dendritic Cell Ratio. Inflamm Bowel Dis. 2018 Jan 18;24(2):317-331.
7. Uchiyama K, Takagi T, Kashiwagi S, Toyokawa Y, Tanaka M, Hotta Y, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Ishikawa T, Handa O, Konishi H, Kishimoto M, Yagi N, Naito Y, Itoh Y. Assessment of Endoscopic Mucosal Healing of Ulcerative Colitis Using Linked Colour Imaging, a Novel Endoscopic Enhancement System. J Crohns Colitis. 2017 Aug 1;11(8):963-969.
8. Takagi T, Naito Y, Uchiyama K, Mizuhima K, Suzuki T, Horie R, Hirata I, Tsuboi H, Yoshikawa T. Carbon monoxide promotes gastric wound healing in mice via the protein kinase C pathway. Free Radic Res. 2016 Oct;50(10):1098-1105. Epub 2016 Jun 2.
9. Takagi T, Naito Y, Higashimura Y, Ushiroda C, Mizushima K, Ohashi Y, Yasukawa Z, Ozeki M, Tokunaga M, Okubo T, Katada K, Kamada K, Uchiyama K, Handa O, Itoh Y, Yoshikawa T. Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA. Br J Nutr. 2016 Oct;116(7):1199-1205.
10. Steiger C, Uchiyama K, Takagi T, Mizushima K, Higashimura Y, Gutmann M, Hermann C, Botov S, Schmalz HG, Naito Y, Meinel L. Prevention of colitis by controlled oral drug delivery of carbon monoxide. J Control Release. 2016 Oct 10;239:128-36.
11. Takagi T, Uchiyama K, Naito Y. The therapeutic potential of carbon monoxide for inflammatory bowel disease. Digestion. 2015;91(1):13-8.
12. Harusato A, Naito Y, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Higashimura Y, Katada K, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Muto A, Igarashi K, Yoshikawa T. BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: role of M2 macrophages and heme oxygenase-1. Inflamm Bowel Dis. 2013 Mar-Apr;19(4):740-53.
13. Aoi W, Naito Y, Takagi T, Tanimura Y, Takanami Y, Kawai Y, Sakuma K, Hang LP, Mizushima K, Hirai Y, Koyama R, Wada S, Higashi A, Kokura S, Ichikawa H, Yoshikawa T. A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise. Gut. 2013 Jun;62(6):882-9.
14. Takagi T, Naito Y, Oya-Ito T, Yoshikawa T. The role of methylglyoxal-modified proteins in gastric ulcer healing. Curr Med Chem. 2012 Jan 1;19(1):137-44.
15. Takagi T, Naito Y, Uchiyama K, Okuda T, Mizushima K, Suzuki T, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T. Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution. World J Gastroenterol. 2011 Sep 7;17(33):3802-9.
16. Takagi T, Naito Y, Uchiyama K, Suzuki T, Hirata I, Mizushima K, Tsuboi H, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Ichikawa H, Yoshikawa T. Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice. Dig Dis Sci 56: 1663-1671, 2011.
17. Takagi T, Naito Y, Okuda T, Uchiyama K, Adachi S, Mizushima K, Handa O, Kokura S, Ichikawa H, Yoshikawa T. Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells. J Gastroenterol Hepatol 25: 1259-1265, 2010.
18. Takagi T, Naito Y, Mizushima K, Akagiri S, Suzuki T, Hirata I, Omatsu T, Handa O, Kokura S, Ichikawa H, Yoshikawa T. Inhalation of Carbon Monoxide Ameliorates TNBS-Induced Colitis in Mice Through the Inhibition of TNF-alpha Expression. Dig Dis Sci. 2010 Jan 22.
19. Takagi T, Naito Y, Okada H, Ishii T, Mizushima K, Akagiri S, Adachi S, Handa O, Kokura S, Ichikawa H, Itoh K, Yamamoto M, Matsui H, Yoshikawa T. Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 1. J Pharmacol Exp Ther. 2009 Oct;331(1):255-64.
20. Takagi T, Naito Y, Inoue M, Akagiri S, Mizushima K, Handa O, Kokura S, Ichikawa H, Yoshikawa T. Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and MCP-1. Inflammation. 2009 Apr;32(2):83-8