専　門

• 消化器病学
• 消化器内視鏡学
• がん治療学
• がん免疫治療学
• 温熱療法

所属学会

• 内科学会
• 消化器病学会
• 消化器内視鏡学会
• 日本ハイパーサーミア学会

業　績

1. Takagi T, Naito Y, Okada H, Okayama T, Mizushima K, Yamada S, Fukumoto K, Inoue K, Takaoka M, Oya-Ito T, Uchiyama K, Ishikawa T, Handa O, Kokura S, Yagi N, Ichikawa H, Kato Y, Osawa T, Yoshikawa T. Identification of dihalogenated proteins in rat intestinal mucosa injured by indomethacin. J Clin Biochem Nutr. 2011 Mar;48(2):178-82. Epub 2011 Feb 26.
2. Kokura S, Adachi S, Mizushima K, Okayama T, Hattori T, Okuda T, Nakabe N, Manabe E, Ishikawa T, Handa O, Takagi T, Naito Y, Yoshikawa T. Gene expression profiles of diabetic mice treated with whole body hyperthermia: A high-density DNA microarray analysis. Int J Hyperthermia. 2010;26(2):101-7.
3. Adachi S, Kokura S, Okayama T, Ishikawa T, Takagi T, Handa O, Naito Y, Yoshikawa T. Effect of hyperthermia combined with gemcitabine on apoptotic cell death in cultured human pancreatic cancer cell lines. Int J Hyperthermia. 2009 May;25(3):210-9.
4. Hirata I, Naito Y, Handa O, Hayashi N, Mizushima K, Adachi S, Omatsu T, Okayama T, Kishimoto E, Ichikawa H, Takagi T, Kokura S, Otaka M, Yoshikawa T. Heat-shock protein 70-overexpressing gastric epithelial cells are resistant to indomethacin-induced apoptosis. Digestion. 2009;79(4):243-50. Epub 2009 Apr 28.
5. Okayama T, Kokura S, Ishikawa T, Adachi S, Hattori T, Takagi T, Handa O, Naito Y, Yoshikawa T. Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice. Int J Hyperthermia. 2009 Mar;25(2):141-9.
6. Okayama T, Yoshida N, Uchiyama K, Takagi T, Ichikawa H, Yoshikawa T. Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis. J Gastroenterol. 2009;44 Suppl 19:35-9. Epub 2009 Jan 16.
7. Omatsu T, Naito Y, Handa O, Hayashi N, Mizushima K, Qin Y, Hirata I, Adachi S, Okayama T, Kishimoto E, Takagi T, Kokura S, Ichikawa H, Yoshikawa T. Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells. J Gastroenterol. 2009;44 Suppl 19:30-4. Epub 2009 Jan 16.
8. Takagi T, Naito Y, Mizushima K, Nukigi Y, Okada H, Suzuki T, Hirata I, Omatsu T, Okayama T, Handa O, Kokura S, Ichikawa H, Yoshikawa T. Increased intestinal expression of heme oxygenase-1 and its localization in patients with ulcerative colitis. J Gastroenterol Hepatol. 2008 Dec;23 Suppl 2:S229-33.
9. Hattori T, Kokura S, Okuda T, Okayama T, Takagi T, Handa O, Naito Y, Yoshida N, Yoshikawa T. Antitumor effect of whole body hyperthermia with alpha-galactosylceramide in a subcutaneous tumor model of colon cancer. Int J Hyperthermia. 2007 Nov;23(7):591-8.