Doctors

消化器内科学教室 スタッフ紹介

学内講師 Assistant Professor
楳村 敦詩 Atsushi Umemura, M.D., Ph.D.

出身地 愛知県

略 歴

2000年 京都府立医科大学卒業
2007年 京都府立医科大学大学院修了
2007年 大阪府済生会吹田病院 消化器内科
2011年 カリフォルニア大学サンディエゴ校研究員
2015年 京都府健康福祉部健康対策課・医療課 医務主幹
京都府立医科大学消化器内科 助教(併任)
2016年 京都府立医科大学消化器内科 助教
2020年 京都府立医科大学消化器内科 学内講師
現在に至る

専 門

  • 消化器病学
  • 肝臓病学
  • 腫瘍学、発がん機構の解明、炎症・肥満とがん
  • NAFLD/NASH

所属学会

  • 日本内科学会総合内科専門医
  • 日本消化器病学会専門医
  • 日本肝臓学会肝臓専門医・指導医
  • 米国肝臓学会(AASLD) international member
  • 日本がん治療認定医機構がん治療認定医

業 績

  1. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11;32(6):824-839.e8.
  2. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 Jun 13;29(6):935-48.
  3. Zhong Z*, Umemura A* (*; Co-first author), Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-kB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25;164(5):896-910.
  4. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13;162(4):766-79.
  5. Nakagawa H*, Umemura A* (*; Co-first author), Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Randal J. Kaufman, and Michael Karin. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 8;26(3):331-43.
  6. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition. Cell Metab. 2014 Jul 1;20(1):133-44.
  7. Shima T, Seki K, Umemura A, Ogawa R, Horimoto R, Oya H, Sendo R, Mizuno M, Okanoue T. Influence of lifestyle-related diseases and age on the development and progression of nonalcoholic fatty liver disease. Hepatol Res. 2014 Jun 30.
  8. Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1090-5.
  9. akurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. p38α Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species. Cancer Res. 2013 Jan 1;73(1):215-24.
  10. Kawaguchi T, Sumida Y, Umemura A, Matsuo K, Takahashi M, Takamura T, Yasui K, Saibara T, Hashimoto E, Kawanaka M, Watanabe S, Kawata S, Imai Y, Kokubo M, Shima T, Park H, Tanaka H, Tajima K, Yamada R, Matsuda F; Takeshi Okanoue, Japan Study Group of Nonalcoholic Fatty Liver Disease.
    Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. PLoS One. 2012;7(6):e38322.
  11. Okanoue T, Umemura A, Yasui K, Itoh Y. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan. J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:153-62.
  12. Umemura A, Itoh Y, Itoh K, Yamaguchi K, Nakajima T, Higashitsuji H, Onoue H, Fukumoto M, Okanoue T, Fujita J. Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma.
    Hepatology. 2008 Feb;47(2):493-502.

お問い合わせ
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TEL:075-251-5519(医局)FAX:075-251-0710(医局)消化器内科医局 mail: s-ikyoku@koto.kpu-m.ac.jp